Towards pathway‐centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway
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چکیده
منابع مشابه
Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway
BACKGROUND Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the heterogeneity challenge is a shift from gene-centric to pathway-centric therapies. Pathway-centric perspectives, which underscore the need to under...
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ژورنال
عنوان ژورنال: Clinical and Translational Medicine
سال: 2015
ISSN: 2001-1326,2001-1326
DOI: 10.1186/s40169-015-0066-1